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Combined BRAF and MEK Inhibition versus BRAF …https://www.nejm.org/doi/full/10.1056/NEJMoa1406037Targeted inhibition of the RAF–MEK–ERK (MAPK) pathway with BRAF inhibitors dabrafenib or vemurafenib, as compared with chemotherapy, improves the progression-free and overall survival of patients who have metastatic melanoma with BRAF V600 mutations. 1,2 However, resistance develops in a majority of patients, resulting in a …

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Zastava Koral - Wikipediahttps://en.wikipedia.org/wiki/YUGOEarlier models. Yugo 45 derivative models have included the Yugo 55, 60, 65, Koral, Ciao, Tempo, Cabrio, GV, GV Plus, GVX, and GVL. Yugo engines were fitted with a carburetor until well into the 1980s before fuel-injected models (starting with the Koral 65) were introduced beginning with the GVX-EFI (an electronic fuel injection system), which ...

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en.wikipedia.org/wiki/YUGO

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场次表 Schedule | Singapore Chinese Film Festival 2018scff.sg/scheduleTitle (English) Rating Date & Time Venue Tickets; 人物纪录片: 导演与传主之间 Bio Documentaries: Exploring the Relationship Between Subject and Filmmaker [90min]

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